Johnny Galecki (ROSEANNE) and Jim Parsons (JUDGING AMY) star as two geeky scientists who are accustomed to probing the secrets of the universe, but totally inept when it comes to the greatest mystery of all: women. Their lives are turned upside down with the arrival of Penny (Kaley Cuoco), a beautiful blonde who moves in next door and gets their Bunsen burners all fired up. Plenty of high jinks ensue as the two clueless roommates receive a crash course in the ways of the opposite sex.

Episodes comprise:

1. The Bad Fish Paradigm
2. The Codpiece Topology
3. The Barbarian Sublimation
4. The Griffin Equivalency
5. The Euclid Alternative
6. The Cooper-Nowitzki Theorem
7. The Panty Piñata Polarization
8. The Lizard-Spock Expansion
9. The White Asparagus Triangulation
10. The Vartabedian Conundrum
11. The Bath Item Gift Hypothesis
12. The Killer Robot Instability
13. The Friendship Algorithm
14. The Financial Permeability
15. The Maternal Capacitance
16. The Cushion Saturation
17. The Terminator Decoupling
18. The Work Song Nanocluster
19. The Dead Hooker Juxtaposition
20. The Hofstadter Isotope
21. The Vegas Renormalization
22. The Classified Materials Turbulence
23. The Monopolar Expedition