Set in Portland, Oregon, Huff centers on the life of 40-something good-guy psychiatrist Dr. Craig "Huff" Huffstodt (Hank Azaria) suffering from a midlife crisis. Huff's world includes his lovely but complicated wife, Beth (Paget Brewster), a teenage son named Byrd (Anton Yelchin) who is mature beyond his years, and Huff's overprotective and domineering mother, Izzy (Blythe Danner), who just so happens to live in the guesthouse. Complicating matters is Huff's best friend Russell Meeks (Oliver Platt), a fearless attorney with somewhat questionable ethics.