Felicity Huffman plays an uptight male-to-female transsexual named Sabrina Bree Osbourne (nee Stanley). Bree's life takes a sudden turn when she receives a phone call from New York. Her son, Toby (Kevin Zegers), has been jailed, and Bree needs to post bail for him. The only problem is, Bree didn't know she had a son, but her therapist refuses to give her written permission to have the final part of her sex-change operation if she doesn't go, so Bree heads east from her California home...