Clash of the Titan soars to top of US box office
The 3D film, which stars Sam Worthington, took $61.4 million (£40.3 million) over the Easter break.
Why Did I get Married Too? debuted at two, after taking $30.2 million.
The film, which is directed by Tyler Perry, tells the story of four couples who reunite for their annual vacation in order to socialise and to spend time analysing their marriages.
Starring Perry, Janet Jackson, Jill Scott, Sharon Leal, Malik Yoba, Richard T. Jones and Tasha Smoth, the film is the sequel to 2007's Why Did I get Married.
Last week's number one How to Train your Dragon fell to the third place, ahead of the new Miley Cyrus film The Last Song, which opened at four.
Tim Burton's 3D fantasy flick Alice in Wonderland fell three places to five, while the Hot Tub Machine also fell to six.
The Bounty Hunter, Diary of a Wimpy Kid, She's Out of my League and Shutter Island rounded off the top ten.