Oscar shout for Depp
Other big winners last night were Charlize Theron, who won best actress, and Rene Zelwegger - who added to her best supporting actress Bafta with the equivalent SAG award.
Johnny Depp beat off fellow Oscar nominees Bill Murray and Sean Penn to win the award for his performance in "Pirates of the Caribbean".
"Lord of the Rings: Return of the King" won best cast. John Rhys-Davies, who plays Gimli the dwarf in the film, said: "At the risk of sounding immodest, we deserved this award.
"This is the most enormous undertaking in film history."